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CLL is closely related to (and most consider it the same as) a disease called small lymphocytic lymphoma (SLL), a type of non-Hodgkin's lymphoma which presents primarily in the lymph nodes.Note: Splenic Lymphoma is very difficult to diagnose and often misdiagnosed for CLL."Chronic lymphocytic leukaemia (CLL) is a B-cell disorder, which has a median survival of over 10 years from diagnosis for stage A disease.It is sometimes considered or classified as a lymphoma."Small lymphocytic lymphoma (SLL) is almost identical to CLL both morphologically (in appearance under the microscope) and clinically (how it behaves and is treated).In 1994, SLL and CLL were combined into one diagnosis, CLL/SLL.Some trials require the CLL diagnosis so that cells can be collected from the peripheral blood. It is important to remember that a bone marrow biopsy of 30% CLL cells qualifies someone as CLL.Anemia and thrombocytopenia are the major adverse prognostic variables. The Rai staging system and the Binet classification are presented below.[1,2] A National Cancer Institute (NCI)-sponsored working group has formulated standardized guidelines for eligibility, response, and toxic effects criteria to be used in future clinical trials in CLL." Staging helps to determine the risk of the CLL based on clinical factors (how it has behaved and advnaced so far).Staging can be more reliable than cytogenetic findings (which are investigational in many cases) for guiding clinical decisions.
Back then, a lymph node read by a pathologist was SLL, but a bone marrow biopsy (or peripheral blood) would be read as CLL.
Overview | Natural History | Statistics | Risk Factors | Signs and Symptoms | Diagnosis | Workup | Essential resources Treatment | Clinical Trials | Prognostic Factors | Staging | Targets | Richter's Syndrome CLL Society Ro Regarding CLL and SLL, by Dr.
Furman as of 1/2015: CLL and SLL are the identical disease.
Therefore, there is just CLL/SLL (dropped the "B" because they are all B-cells).
Chronic lymphocytic leukemia (CLL) is caused by the overproduction of abnormal b lymphocytes (a type of white blood cell).